Treatment of Dementia in Parkinsonian Patients
نویسندگان
چکیده
Among the patients with Parkinson’s disease, 85% show symptoms of a mild cognitive impairment and 40% develop criteria of dementia. Increased levels of glutamate, noradrenaline and serotonin can be found. Diagrams of neural pathways in the extrapyramidal system and hippocampus and temporal cortex are described and compatible treatments for both syndromes are derived. Besides a conventional treatment with the cholinesterase inhibitor, NMDA antagonists, in combination with a decarboxylase inhibitor and selegeline could be administered additionally.
منابع مشابه
Treatment of dementia in parkinsonian syndromes with cholinesterase inhibitors.
In Parkinsonian syndromes behavioural symptoms and dementia can be even more debilitating than motor symptoms and are an important predictor for nursing home placement and mortality. Neuropathologically, dementia seems to be primarily related to cortical changes rather than to subcortical alterations. Concerning neurotransmitter systems, the cholinergic system has been proposed to play a key ro...
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